Vol 53, No.5
May  2021
Impact Factor: 2.836
Editor-in-Chief: Jianping Ding
View full editorial board
Institute of Biochemistry & Cell Biology, SIBS, CAS
Chinese Academy of Sciences
WANG Ying-Lai Foundation
China Association for Science and Technology
Project for Enhancing International Impact of China STM Journals
International Association for Biological and Medical Research
Selected Articles from the Current Issue
Lipid metabolism in cartilage and its diseases: a concise review of the research progress
Yueyi Yang, Jieya Wei, Jiachi Li, Yujia Cui, Xuedong Zhou, and Jing Xie

Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice
Pengfei Liu, Quansheng Gao, Lei Guan, Yanting Hu, Jingwen Jiang, Teng Gao, Weixuan Sheng, Xinying Xue, Hui Qiao, and Tianzuo Li

Complete Freund¨s adjuvantCinduced decrement of pruriceptor-mediated suppression of itch
Wen Yin, Li Liu, Yuxi Zhou, Yunchun Zhang, Dexu Kong, Saihong Xu, Dan Tang, Dan Huang, Daxiang Wen, Yingfu Jiao, Yinghui Fan, Po Gao, and Weifeng Yu

Amplification and expression of c-MET correlate with poor prognosis of patients with gastric cancer and upregulate the expression of PDL1
Ya¨nan Yang, Chenchen Wang, Congqi Dai, Xinyang Liu, Wenhua Li, Mingzhu Huang, Xiaoying Zhao, Dongmei Ji, Jin Li, and Weijian Guo

Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis
Guangyue Luo, Yangyang Zhang, Zhonghui Wu, Ligang Zhang, Chaozhao Liang, and Xianguo Chen

Elevated ZIPK is required for TNF-α-induced cell adhesion molecule expression and leucocyte adhesion in endothelial cells
Weiwei Zeng, Zhiyuan Sun, Tengxiang Ma, Xiaobin Song, Shuai Li, Qianqian Zhang, Wen Yuan, Jing Li, Li Liu, Minsheng Zhu, and Huaqun Chen

Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K‒AKT‒mTOR/JNK pathway
Ke Hu, Bo Li, Ruye Ma, Hongfei Yi, Zhijian Xu, Yu Peng, Dandan Yu, Huiqun Wu, Taofang Cheng, Yumeng Lu, Yong Zhang, Rong Wei, Guang Yang, Xiaosong Wu, Weiliang Zhu, and Jumei Shi

PBK/TOPK promotes chemoresistance to oxaliplatin in hepatocellular carcinoma cells by regulating PTEN
Hongmin Cao, Mei Yang, Yufeng Yang, Jiayan Fang, and Yejia Cui

Effects of CMYA1 overexpression on cardiac structure and function in mice
Chunyan Li, Hongliang Zhang, Yuanyuan Xie, Shenghua Liu, Ranxu Zhao, Jian Huang, Jie Huang, and Yingjie Wei

Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome
Jiangwen Dai, Qingsong Chen, Weifeng Huang, Kun Shi, Yuke Zhang, Tingting Li, Tong Mou, Zuotian Huang, and Zhongjun Wu

CCL26 is upregulated by nab-paclitaxel in pancreatic cancerCassociated fibroblasts and promotes PDAC invasiveness through activation of the PI3K/AKT/mTOR pathway
Xuemin Chen, Yong An, Yue Zhang, Dong Xu, Tongbing Chen, Yue Yang, Weibo Chen, Di Wu, and Xiaoying Zhang

A modified pCas/pTargetF system for CRISPR-Cas9-assisted genome editing in Escherichia coli
Qi Li, Bingbing Sun, Jun Chen, Yiwen Zhang, Yu Jiang, and Sheng Yang

The binding epitope of sintilimab on PD-1 revealed by AbMap
Mingliang Ma, Huan Qi, Chuansheng Hu, Zhaowei Xu, Fanlin Wu, Nan Wang, Danyun Lai, Yang Li, Hainan Zhang, Hewei Jiang, Qingfeng Meng, Shujuan Guo, Yani Kang, Xiaodong Zhao, Hua Li, and Sheng-ce Tao

Highlighted Articles  
Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells

Atorvastatin blocks increased l-type Ca2+ current and cell injury elicited by angiotensin II via inhibiting oxide stress

Bacillus thuringiensis peptidoglycan hydrolase SleB171 involved in daughter cell separation during cell division

Leukocyte populations and IL-6 in the tumor microenvironment of an orthotopic colorectal cancer model

YB-1, a new biomarker of glioma progression, is associated with the prognosis of glioma patients

Ethanol-related alterations in gene expression patterns in the developing murine hippocampus

The receptor proteins: pivotal roles in selective autophagy

Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma

Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase

Angiotensin II induces an increase in MMP-2 expression in idiopathic ascending aortic aneurysm via AT1 receptor and JNK pathway

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